1.1 What's New

1.1.1  TreeAge Pro 2025, Release 1

New for TreeAge Pro Healthcare:

• Markov Model Building Wizard *

  • With the Markov Model Wizard, you can create your model in a few simple steps.

  • It’s never been easier to build a Markov Model with TreeAge Pro.

• Markov Plot View *

  • The Markov Plot View allows you to create a graphical representation of Markov disease progression with a single click. You can overlay the Markov Plot with survival tables to see how closely your model matches with source clinical data.

  • You can then adjust your model pathways and/or event probabilities to better match the source data, resulting in a more accurate model.

• Survival to Hazard Conversion Enhancements

  • New conversion options better match survival by applying hazards earlier.

  • Support for spline tables.

• New Table Controls and Functions

  • Support spline interpolation.

  • Allow use of 0 when table lookups go beyond the edges of a table.

  • New function for reverse table lookups.

• Allow Negative Distribution Parameters

  • Gompertz and Generalized Gamma distribution types.

• Combine Survival Curve Graphs

  • From Partitioned Survival models and Markov model PartSA output graph.

• Add Point to Graph

  • Add a specific point to any graph to highlight values.

* Features require your license have active Maintenance.

1.1.2  TreeAge Pro 2024, Release 2

New for TreeAge Pro Healthcare:

• Visualize Survival Estimates with the Survival Plot: Compare different estimates of survival with the Survival Plot View. Compare survival and/or hazard functions from distributions, tables and formulas to determine which is most accurate and appropriate for your model. No model structure is required, just add survival/hazard series and review the graphs. Export your survival estimate comparison to image or PDF files to share with colleagues.

• Share Patient Simulation Models over the Web: Share patient simulation/microsimulation models over the web. Setup the model for sharing within TreeAge Pro, then upload the model to TPWeb.treeage.com to share it with colleagues.

• Share Models with Everyone over the Web: Share your models on TPWeb with the world, perhaps in support of a paper publication. The existing sharing option to share with an individual remains the default sharing option.

• Calculate Hazard/Risk from Distributions: Calculate instantaneous risk over time from time-to-event distributions. For years, you could calculate survival over time from a distribution using the DistSurv function. The new DistHazard function allows you to use the same distributions to calculate instantaneous risk, which allows you to combine different risks seamlessly within the hazard domain.

1.1.3  TreeAge Pro 2024, Release 1

New for TreeAge Pro Healthcare:

• Web Model Sharing: Share your model on the web. You define the web functionality by choosing which inputs can be edited and which analyses can be run. Then share the model with colleagues, so they can review and analyze the model.

• Add Distribution Wizard: Select a model input to include in Probabilistic Sensitivity Analysis. With just a few mouse clicks, the wizard creates the appropriate distribution and references it in the model.

• Generate Simulation Dashboard Graphs: Many modelers liked the dashboard graphs presented in Monte Carlo Simulation Dashboards. You can now generate those graphs in independent windows with graph and export options.

1.1.4  TreeAge Pro 2023, Release 2

New for TreeAge Pro Healthcare:

• New HTML Help: TreeAge Pro documentation is now presented in a more user-friendly HTML format within a browser. You can multiple browser tabs for different help topics.

• Modeling with Hazards: Integrate hazard functions into your model to more accurately model disease progression.

  • Calculating Hazards from Survival Data: Convert survival data to hazards for additional flexibility related to modeling with health risks. Also convert to validate model results to ensure that they accurately represent health risks.

  • Editing and Extending a Hazard Table: Use the hazard table editor to modify hazards and examine how the risk changes affect survival.

  • Using Hazards in a PartSA Model: Integrate hazards into a Partitioned Survival model by defining survival using hazard functions.

  • Using Hazards in a DES Model: Integrate hazards into a Discrete Event Simulation model using a HazardTable or HazardExpression distribution for time-to-event.

  • Using Hazards in a Markov Model: Integrate hazards into a Markov model by calculating event probabilities based on changing hazards/risks over time.

  • Sensitivity Analysis with Hazards: Apply sensitivity analysis to hazard tables.

  • Survival Curve and Hazard Curve Graphs: Generate Hazard Curve graphs as well as Survival Curve graphs for the survival curve nodes (i.e., PFS, OS) in your model.

  • Plot Distribution Survival and Hazards: New control in the Distributions View allows you to plot survival and hazards from survival-related distributions. Both survival and hazards can be exported to tables.

• Sensitivity Analysis on Tables: Expand table data to three value columns to support sensitivity analysis. This can help you apply sensitivity analysis to time-depending values in your model.

• Export Survival to Table: Export survival data from Markov Cohort Analysis Output to a survival table. You can then convert it to hazards to assess/validate risk in your model.

• Distribution Minimum PartSA Time: Provide a minimum time in PartSA models for survival-based distributions that are undefined at _time 0.

1.1.5  TreeAge Pro 2023, Release 1

New for TreeAge Pro Healthcare:

• New Markov Cohort Dashboard

  • Markov Cohort Analysis results are now consolidated into a single dashboard with access to all cohort reports and graphs that show detailed calculations.

  • New graphical outputs for additional model outputs.

• Simulation Mean Prediction Intervals

  • Monte Carlo Simulation (Microsimulation & PSA) and histogram outputs show mean values and prediction intervals. These new statistics help you determine how stable simulation means are based on the width of the prediction interval.

  • Histogram options to show trendlines, mean and mean prediction interval.

• Batch Simulation Runs

  • Run a batch of any Monte Carlo simulation to see how stable results are from run to run. This can help determine if your simulation included enough iterations.

New for TreeAge Pro Healthcare & TreeAge Pro Business:

• Distribution Parameters from SAS, Stata, R

  • Create distributions with parameters generated from several statistical packages.

• Sensitivity Analysis Outputs for Extra Payoffs

  • Sensitivity Analysis Dashboards now include links to graphs that show how additional model outputs change with your selected input parameter.

• Tornado Diagrams for Extra Payoffs

  • Tornado Dashboards now include links to graphs that show how additional model outputs change with your selected input parameters in a new tornado diagram.

• Paste nodes/subtrees to multiple target nodes

  • Copy a node or subtree and paste it to multiple locations.

1.1.6  Details about earlier releases

To find details about the features which were made available with earlier releases, please visit our website: www.treeage.com/news